External Resources:

Susan Ackerman, Ph.D.

Professor of Cellular and Molecular Medicine and Steven Kuffler Chair of Biology (Neurobiology)
Howards Hughes Medical Institute Investigator

Website: https://www.hhmi.org/scientists/susan-l-ackerman
Email: sackerman@ucsd.edu

Pathways/processes: Neurodevelopment and nerodegeneration, RNA metabolism, Translational regulation, Signaling Pathways during cellular stress, Proteostasis
Teams/collaborations: Joe Gleeson, Alysson Muotri, Gene Yeo
Approaches: Forward and Reverse Genetics, Mouse Models, Modifier genes, Transcriptomics, Ribosome Profiling
Diseases: Cerebellar Ataxis, Neurodegenerative disorders

The goal of our laboratory is to define the molecular pathways necessary to maintain homeostasis in both developing and aging mammalian neurons. To do this we utilize forward genetics to identify mutations that are associated with loss of neurons in the aging mouse brain. To further dissect pathways underlying homeostatic disruption and disease, we also use forward genetics to identify genetic variants that enhance or suppress neural phenotypes. Our approach allows the identification, without priori assumptions, of molecules critical for neuron homeostasis and survival, and indeed we have discovered disruptions in several novel pathways that were not previously associated with loss of neuronal function or survival. We are particularly interested in the role of alterations in translation elongation, translational fidelity, proteostasis, and RNA metabolism in neuronal function.