Institute for Genomic Medicine

Miles Wilkinson, Ph.D.

Professor of Reproductive Medicine

Website: Miles Wilkinson - Department of Reproductive Medicine
Email: mfwilkinson@ucsd.edu

Pathways/processes: Transcription, epigenetics (DNA methylation and histone modifications), RNA splicing, RNA stability, NMD RNA surveillance pathway
Teams/collaborations: n/a
Approaches: KO and KD mice, genome-wide gene expression, reproductive organs, stem cells, neural progenitors
Diseases: X-linked mental retardation, diseases caused by nonsense and frameshift mutations

Research

Our laboratory primarily works on two topics: (1) transcriptional regulatory pathways that control embryonic stem cell and germ cell development in vivo, and (2) RNA surveillance pathways that serve as quality-control mechanisms to degrade or “correct” aberrant transcripts that would otherwise express truncated proteins causing developmental defects and/or cancer.