Section 'Sub' Navigation:
Jonathan Sebat, Ph.D.
Chief, Beyster Center for Molecular Genomics of Neuropsychiatric Diseases
Pathways/processes: Genetics of Neuropsychiatric Disorders, Structural Genomic Variation
The Sebat laboratory is interested in understanding the molecular basis of neuropsychiatric disorders including schizophrenia, bipolar disorder and autism. We are interested the role of copy number variants (CNVs) in disease. Our approach is to apply advanced mutation-detection methods, including microarray and Next Generation Sequencing (NGS) technologies, to identify mutations that confer high risk of disease. Further, we are investigating the functional impact of CNVs on genes and corresponding cellular pathways.