Institute for Genomic Medicine

Professor of Psychiatry and Cellular and Molecular Medicine Chief, Beyster Center for Molecular Genomics of Neuropsychiatric Diseases Phone: 858-822-1023 Website: Department of Psychiatry profile Email: jsebat@ucsd.edu Pathways/processes: Genetics of Neuropsychiatric Disorders, Structural Genomic Variation Teams/collaborations: Gene Yeo, John Kelsoe, Ming Tsuang, Joe Gleeson Approaches: Microarray Comparative Genomic Hybridization (CGH), Next Generation Sequencing (NGS) Diseases: Schizophrenia, Bipolar Disorder, Autism Spectrum Disorders

Research

The Sebat laboratory is interested in understanding the molecular basis of neuropsychiatric disorders including schizophrenia, bipolar disorder and autism. We are interested the role of copy number variants (CNVs) in disease. Our approach is to apply advanced mutation-detection methods, including microarray and Next Generation Sequencing (NGS) technologies, to identify mutations that confer high risk of disease. Further, we are investigating the functional impact of CNVs on genes and corresponding cellular pathways.