External Resources:

Al La Spada, M.D., Ph.D.

Professor of Pediatrics and Cellular and Molecular Medicine
Associate Director, IGM

Website: http://healthspan.ucsd.edu/2009/08/Pages/som-laspada.aspx
Email: alaspada@ucsd.edu

Pathways/processes: Neurogenetics; autophagy; protein turnover; transcription regulation; non-coding RNAs; mitochondrial function
Teams/collaborations: Joe Gleeson, Bruce Hamilton, Kang Zhang, Terry Gaasterland, Trey Ideker, Kelly Frazer, Gene Yeo, Muotri, Christopher Glass, Xiang-Dong Fu, Cleveland, Goldstein
Approaches: Array analysis, proteomics, transgenesis & gene targeting, high throughput sequencing, bioinformatics
Diseases: Huntington's disease, motor neuron disease, cerebellar degeneration, movement disorders

Research

In the La Spada laboratory, we apply the tools of genetics, genomics, biochemistry and neuroscience to understand how neurons function, to determine mechanisms of neurodegenerative disease, and to develop meaningful therapies for neurological disorders.