External Resources:

Xiang-Dong Fu, Ph.D.

Professor of Cellular and Molecular Medicine

Email: xdfu@ucsd.edu

Pathways/processes: n/a
Teams/collaborations: Christopher Glass, Bruce Hamilton, Gene Yeo
Approaches: CLIP, ChIP, next-generation sequencing
Diseases: Cancer, Heart disease


Gene expression is regulated at both the transcriptional and post-transcriptional levels. Our lab has been focusing on post-transcriptional regulation of gene expression, with a particular emphasis on the mechanism, regulation, and biological consequences of alternative mRNA processing. More recently, the research scope of our lab has been expanded to mechanistic coupling between transcription and splicing, the nuclear architectural basis for regulated gene expression, and genomics of RNA binding proteins.

We have been using several disease models for our basic research, including the cardiovascular system to understand regulated splicing during heart remodeling and the breast and prostate cancer cell lines to dissect the molecular mechanisms underlying the development of hormone refractory tumors. We are also using the latest genomics technologies to develop chemical genetics strategies, which have certain translational potentials for disease intervention.