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Bringing Genomics and Systems Biology to Pathways and Disease

Within the last two decades, we have witnessed unprecedented progress in genomics and genetics research. The availability of complete genome sequences and systematized catalogs of genetic variation in humans, human pathogens, and other model organisms have had a major impact on biology and have begun to transform clinical practice. The advances in whole genome amplification, genotyping platforms, next generation sequencing, and the coming advent $1000 genome will continue to drive innovation and discovery.

We are on the verge of routine acquisition of whole genome information from individual human subjects using new sequencing technologies – on a large scale with an affordable cost. In collaboration with Cal-IT2 and the San Diego Supercomputer Center, the UCSD Institute for Genomic Medicine aims to harness clinically relevant information from the vast amounts of genetic sequence data being generated by new genomic technologies.

Approaches

Genetics

Inherited disorders in patients and animal models often provide the first insights into new disease mechanisms. IGM investigators are using family studies, genetics susceptibility in populations, and experimental systems in animals and cells to identify and dissect genes and gene variants that play key roles in health and disease.

Genomics

We are dedicated to utilizing cutting-edge genome-wide technology such as high-throughput next-generation sequencing, mass spectroscopy and chip-based synthesis of nucleotides to make precise, nucleotide resolution measurements of molecular changes that are diagnostic for disease for prediction and therapy.

Systems-level Analysis

Integration of genomic information with interactomes and evolutionary maps will be leveraged strongly by us to isolate key pathways malfunctioning in human disease for a systems-level approach to diagnostic and treatment.

Pathways

RNA Processing

Members of the IGM have demonstrated excellence and experience in key areas of RNA processing such as nonsense-mediated decay, alternative splicing, microRNA processing and targeting, non-coding RNAs and translational control. We will capitalize on our expertise to illuminate RNA defects in disease areas.

Epigenetics

IGM comprises of experts in the area of epigenetics such as DNA methylation and histone modification, which are growing areas of importance in disease modeling.

Diseases

Neurological and Mental Health Disorders

We have an excellent cadre of leaders applying genetics and genomics approaches to areas neurological and mental health disorders such as epilepsy, ALS, autism, schizophrenia, bipolar disorder and ataxias.

Cancer and DNA-Repair

IGM boasts prominent pioneers in the area of DNA repair and epigenetics as it applies to cancer biology.