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Miles Wilkinson

Miles Wilkinson

Title(s)
Professor of Obstetrics, Gynecology, and Reproductive Sciences


Pathways and Processes
Transcription, epigenetics (DNA methylation and histone modifications), RNA splicing, RNA stability, NMD RNA surveillance pathway
Approaches
KO and KD mice, genome-wide gene expression, reproductive organs, stem cells, neural progenitors
Diseases
X-linked mental retardation, diseases caused by nonsense and frameshift mutations

Transcriptional regulatory pathways in stem cell and germ cell development; Biological functions of nonsense-mediated RNA decay (NMD), a conserved and selective RNA turnover pathway that functions in early embryonic development, neural development, and neural functions.